Multi-color illumination devices that can be used in various indicator-related or ambient lighting applications, particularly for vehicles. In accordance with one embodiment, the multi-color illumination device includes a light guide having a first end and a second end, a first light source located adjacent the first end of the light guide, and a second light source located adjacent the second end of the light guide. The multi-color illumination device is configured for attachment to a controller configured to illuminate the first light source, the second light source, or both the first light source and the second light source in accordance with one or more operation parameters to provide a status indication.