The present invention provides a crossed staggered and stacked-type air packaging device and a manufacturing method therefor. The crossed staged and stacked-type air packaging device includes at least two inflation packaging main body layers, so as to form an accommodation cavity used for storing an article to be packaged. Each inflation packaging main body layer includes at least one sub-inflation unit. The sub-inflation units of at least two adjacent inflation packaging main body layers have different extending directions, so that at least two adjacent inflation packaging main body layers are arranged in a crossed and staggered manner.