Invention Grant
- Patent Title: Adenosine monophosphate-activated protein kinase agonist
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Application No.: US16331388Application Date: 2017-09-06
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Publication No.: US10793527B2Publication Date: 2020-10-06
- Inventor: Chung-Wai Shiau , Jung-Chen Su , Yan-Ju Lin , Jui-Wen Huang
- Applicant: NATIONAL YANG-MING UNIVERSITY
- Applicant Address: TW Taipei
- Assignee: NATIONAL YANG-MING UNIVERSITY
- Current Assignee: NATIONAL YANG-MING UNIVERSITY
- Current Assignee Address: TW Taipei
- Agency: Muncy, Geissler, Olds & Lowe, P.C.
- International Application: PCT/CN2017/100735 WO 20170906
- International Announcement: WO2018/045969 WO 20180315
- Main IPC: C07D233/96
- IPC: C07D233/96 ; A61P35/00 ; C07D239/42 ; C07D401/14 ; A61P3/06 ; C07D403/04 ; C07D409/04

Abstract:
The present invention discloses a compound of the formula (I), which acts as an agonist of adenosine monophosphate-activated protein kinase, which induce phosphorylation and activation of AMPKα, thereby further regulating downstream signaling pathways, inhibiting growth and proliferation of liver cancer cells and breast cancer cells, and also inducing apoptosis of adipocytes. Therefore, the compound provided by the present invention can be utilised for treatment and preparation of pharmaceutical composition for cancer, and lipid metabolism-related diseases or syndromes mediated by AMPK.
Public/Granted literature
- US20190194142A1 AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST Public/Granted day:2019-06-27
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