Invention Grant
- Patent Title: Trimer stabilizing HIV envelope protein mutations
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Application No.: US15704651Application Date: 2017-09-14
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Publication No.: US10793607B2Publication Date: 2020-10-06
- Inventor: Lucy Rutten , Daphné Truan , Nika Mindy Strokappe , Johannes Petrus Maria Langedijk
- Applicant: Janssen Vaccines & Prevention B.V.
- Applicant Address: NL Leiden
- Assignee: Janssen Vaccines & Prevention B.V.
- Current Assignee: Janssen Vaccines & Prevention B.V.
- Current Assignee Address: NL Leiden
- Agency: Ice Miller LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@2b8312dc
- Main IPC: C07K14/15
- IPC: C07K14/15 ; A61K39/21 ; C07K14/16 ; A61K39/12 ; C07K14/005 ; A61K39/00 ; C12N7/02

Abstract:
Human immunodeficiency virus (HIV) envelope proteins having mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins have certain amino acid substitutions at specified positions in the envelope protein sequence. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to an HIV envelope protein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV envelope proteins, nucleic acid, and vectors.
Public/Granted literature
- US20180072777A1 TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS Public/Granted day:2018-03-15
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