Invention Grant
- Patent Title: Human antibodies to Bet v 1 and methods of use thereof
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Application No.: US15994294Application Date: 2018-05-31
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Publication No.: US10793624B2Publication Date: 2020-10-06
- Inventor: Jamie M. Orengo , Andrew J. Murphy , Ashok T. Badithe , Vishal Kamat , Yashu Liu
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: US NY Tarrytown
- Agency: FisherBroyles, LLP
- Agent Cara L. Crowley-Weber; Lisa Dornbach Flanagan
- Main IPC: C07K16/16
- IPC: C07K16/16 ; A61P37/08 ; A61K39/00 ; A61K39/395

Abstract:
Provided herein are antibodies that bind Fagales allergens, Fagales related allergens, birch pollen, or Bet v 1, compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies. According to certain embodiments, the antibodies are fully human monoclonal antibodies that bind to Bet v 1. The antibodies are useful for binding Bet v 1 in vivo, thus preventing binding of the allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the Fagales allergens in sensitized individuals.
Public/Granted literature
- US20180346555A1 HUMAN ANTIBODIES TO BET V 1 AND METHODS OF USE THEREOF Public/Granted day:2018-12-06
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