Invention Grant
- Patent Title: Modified gram positive bacteria and uses thereof
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Application No.: US16713737Application Date: 2019-12-13
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Publication No.: US10793825B2Publication Date: 2020-10-06
- Inventor: Lothar Steidler , Karolien Van Huynegem , Klaas Vandenbroucke
- Applicant: INTREXON ACTOBIOTICS NV
- Applicant Address: BE Zwijnaarde
- Assignee: INTREXON ACTOBIOTICS NV
- Current Assignee: INTREXON ACTOBIOTICS NV
- Current Assignee Address: BE Zwijnaarde
- Agency: Faegre Drinker Biddle & Reath LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@689be330
- Main IPC: C07K1/20
- IPC: C07K1/20 ; A23L1/30 ; C12N1/20 ; C12N9/16 ; C12N9/10 ; C12P19/12 ; C07K14/315 ; A23K10/18 ; A23C9/123 ; A23L33/135 ; C12N1/04 ; C12R1/225 ; C12R1/01 ; A61K39/00
Abstract:
The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
Public/Granted literature
- US20200165564A1 MODIFIED GRAM POSITIVE BACTERIA AND USES THEREOF Public/Granted day:2020-05-28
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