A sealing device for a drive shaft is disclosed and described. The sealing device for a drive shaft comprises a housing disposed to surround the drive shaft between the inner space and the outer space, a plurality of sealing members axially separated from each other between the housing and the drive shaft to seal between the housing and the drive shaft, fixing ring members interposed between the plurality of sealing members to maintain the separation distance between the sealing members, and a fixing member secured to the housing to apply an axial pressure to the plurality of sealing members and fixing ring members, wherein a concave-convex section is formed on at least one of the close surfaces of the fixing ring member and the sealing member, which face each other.