- Patent Title: Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier
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Application No.: US15529936Application Date: 2015-11-27
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Publication No.: US10794899B2Publication Date: 2020-10-06
- Inventor: Takahiro Nishibu , Naoko Imawaka , Ken Naruse , Rikinari Hanayama
- Applicant: FUJIFILM WAKO PURE CHEMICAL CORPORATION , OSAKA UNIVERSITY
- Applicant Address: JP Osaka JP Suita
- Assignee: FUJIFILM WAKO PURE CHEMICAL CORPORATION,OSAKA UNIVERSITY
- Current Assignee: FUJIFILM WAKO PURE CHEMICAL CORPORATION,OSAKA UNIVERSITY
- Current Assignee Address: JP Osaka JP Suita
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@212b84d1
- International Application: PCT/JP2015/083505 WO 20151127
- International Announcement: WO2016/088689 WO 20160609
- Main IPC: G01N33/50
- IPC: G01N33/50 ; C07K1/14 ; C07K17/02 ; G01N33/543 ; G01N33/68 ; C12N15/09 ; C07K17/00 ; C12N7/02 ; C07K14/705 ; G01N33/53 ; G01N15/00 ; G01N15/10 ; G01N15/14
Abstract:
The invention provides a carrier and a method for obtaining, removing, or detecting extracellular membrane vesicle or virus present in a sample. In particular, the invention provides (a) a carrier (a Tim carrier) on which a protein (a Tim protein), selected from a T-cell immunoglobulin and mucin domain-containing molecule-4 (a Tim-4) protein, a Tim-3 protein, and a Tim-1 protein, is bound; (b) a method for obtaining the extracellular membrane vesicle or the virus in the sample; (c) a method for removing the extracellular membrane vesicle or the virus in the sample; (d) a method for detecting the extracellular membrane vesicle or the virus in the sample; (e) a kit for capturing the extracellular membrane vesicle or the virus, comprising the Tim carrier; and f) a kit for capturing the extracellular membrane vesicle or the virus, comprising a reagent containing the Tim protein and a reagent containing the carrier.
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