An information handling system includes a processing unit that is coupled to a memory device by a communication channel. The processing unit includes a memory controller and is configured to host a basic input output system (BIOS). The memory device, which may include a dual in-line memory module (DIMM), stores serial presence detect (SPD) information. In an embodiment, the BIOS obtains the SPD information and parameters of the communication channel, such as channel impedance and channel length. In this embodiment, the BIOS uses a look-up table to determine an equalization of the communication channel based on the obtained SPD information and the obtained parameters of the communication channel, and utilizes the memory controller to set the equalization of the communication channel, such as by setting or controlling settings of transmission and reception components of the memory controller.