Disclosed embodiments relate to a system with configurable cache sub-domains and cross-die memory coherency. In one example, a system includes R racks, each rack housing N nodes, each node incorporating D dies, each die containing C cores and a die shadow tag, each core including P pipelines and a core shadow tag, each pipelines associated with a data cache and data cache tags and being either non-coherent or coherent and one of X coherency domains, wherein each pipeline, when needing to read a cache line, issues a read request to its associated data cache, then, if need be, issues a read request to its associated core-level cache, then, if need be, issues a read request to its associated die-level cache, then, if need be, issues a no-cache remote read request to a target die being mapped to hold the cache line.