A sequence mining platform (SMP) comprises a processor, at least one machine-accessible storage medium responsive to the processor, and a sequence manager in the machine-accessible storage medium. The sequence manager is configured to use processing resources to determine a sequence of nucleobases in a nucleic acid. The storage medium also comprises a blockchain manager to (a) collect transaction data for one or more transactions for a blockchain which requires a proof of work (POW) for each new block; and (b) include at least some of the transaction data in a new block for the blockchain. The storage medium also comprises a sequence mining module (SMM) to use the determined sequence of nucleobases from the sequence manager to create a POW for the new block. In one embodiment, the SMM enables an entity which controls the SMP to receive transaction rewards and sequencing rewards. Other embodiments are described and claimed.