A system and method for the detection of ROIs in images obtained of a breast or other tissue of a patient significantly improves the speed and precision/accuracy of navigation between multimodality 2D and 3D images. In the system and method, images of the tissue are obtained in a DBT acquisition to generate a synthetic 2D image of the imaged tissue and in a 3D, e.g., ultrasound, image acquisition. The 2D image generation process creates a synthetic 2D image that embed a navigation map correlating pixels in the 2D images to sections of the 3D ultrasound volume, such as via a registration between the 3D ultrasound volume and a 3D volume created using the DBT image data. When a synthetic 2D image is reviewed, an ROI on the 2D image is selected and the system will additionally present the user with the section of the 3D volume containing that ROI.