Changes of a vertical and horizontal position of an item are programmatically monitored relative to at least one three-dimensional (3D) item-specific proximity exclusion attribute that precludes movement of the item into a defined 3D item-configured prohibited region by iteratively querying an item tag of the item for measured vertical and horizontal coordinates of the item tag. In response to determining that a detected change of at least one of the vertical and horizontal position of the item results in the item being located within the defined 3D item-configured prohibited region, an item-specific proximity exclusion alert is generated indicating that the item is located within the defined 3D item-configured prohibited region.