A method of manufacturing a fuel cell including a membrane electrode assembly and a resin frame includes, in a membrane electrode assembly sheet that is used for acquiring the membrane electrode assembly, and in which a porous layer including at least a catalytic electrode layer is disposed on at least one surface of an electrolyte membrane, applying a sealing agent onto the porous layer in a region including a part forming an outer periphery of the membrane electrode assembly to seal a pore of the porous layer; acquiring a stack member including the membrane electrode assembly by cutting the membrane electrode assembly sheet in the region; and bonding the resin frame to a part of the porous layer in the stack member where the sealing agent is applied, using an adhesive.