A DC-to-DC converter block with multiple supply voltages includes a power circuit, the power circuit including N depletion-mode HEMT transistors (T3_1, T3_2, T3_N), N being a natural number greater than or equal to 3. The DC-to-DC converter block also includes a gate drive circuit for the N depletion-mode HEMT transistors (T3_1, T3_2, T3_N) of the power circuit, the drive circuit including depletion-mode HEMT transistors (T1_1, T2_1, T1_2, T2_2, T1_N, T2_N) configured to drive the gates of the N depletion-mode HEMT transistors (T3_1, T3_2, T3_N) of the power circuit, and the power circuit being powered by N positive and non-zero supply voltages, namely a lower supply voltage (VDD_1), an upper supply voltage (VDD_N), and (N−2) intermediate supply voltages (VDD_2) distributed between the lower (VDD_1) and upper (VDD_N) supply voltages.