In a multi-user multiple antenna system, a central processor is communicatively coupled to a plurality of geographically distributed access points via a network. The central processor, the geographically distributed access points, or a plurality of client devices served by the system computes channel estimates of wireless channels between the geographically distributed access points and the client devices. The central processor computes access-point weights from the channel estimates to synthesize an antenna array from the plurality of geographically distributed access points, and the access-point weights are used to implement spatial multiplexing.