Invention Grant
- Patent Title: Norrin regulation of junction proteins and the use thereof to treat epithelial or endothelial membrane leakage induced edema
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Application No.: US16218016Application Date: 2018-12-12
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Publication No.: US10799557B2Publication Date: 2020-10-13
- Inventor: Michael T. Trese , Antonio Capone , Kimberly Drenser
- Applicant: RETINAL SOLUTIONS LLC
- Applicant Address: US MI Ann Arbor
- Assignee: RETINAL SOLUTIONS LLC
- Current Assignee: RETINAL SOLUTIONS LLC
- Current Assignee Address: US MI Ann Arbor
- Agency: Blue Filament Law PLLC
- Main IPC: A61K38/18
- IPC: A61K38/18 ; A61P7/10 ; A61P29/00 ; A61P1/00 ; A61P9/10 ; A61P9/14 ; A61K39/395 ; A61K38/17 ; C07K14/475 ; C07K14/515 ; C07K16/22
Abstract:
A method of tightening inter-cellular junctions in endothelial or epithelial cells includes exposing the endothelial or epithelial cells to a norrin in concert with an anti-VEGF agent. Upon sufficient contact time, for norrin to selectively up-regulate gene expression of Cadherin or claudin-5 in the endothelial or epithelial cells, the inter-cellular junctions are tightened.
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Information query
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