Pertussis vaccines and methods of making and using
Abstract:
Bordetella pertussis iron receptor proteins or portions thereof (e.g., one or more extracellular domains), alone or spliced into B. pertussis scaffold proteins (e.g., fimbrial or flagellin), are provided and can be used in acellular vaccines to protect against pertussis or other Bordetella diseases in humans and non-human mammals. In addition, Bordetella species grown under iron-starved conditions are provided and can be used in whole cell vaccines to protect against pertussis or other Bordetella diseases in humans and non-human mammals.
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