The present invention relates to a 3D printing device for multiple materials comprising: a material transfer unit comprising at least two lines; a material supply unit to supply at least one type of printing material on each line of the material transfer unit; a thickness control unit to control a thickness of a material supplied by the material supply unit; a 3D printing module to solidify the material controlled with the thickness by the thickness control unit to a predefined shape to solidify the material on one line and to move to the other line so as to solidify the material on the other line; a material processing module to perform washing or drying for the material solidified by the 3D printing module; and a collecting module to collect the printing material unused during the printing.