The present disclosure relates generally to a connection clip for securing a panel to a support grid, for example, suitable for securing a wood grille panel to a ceiling grid. The present disclosure relates more particularly to a connection clip including a body having a base with a width extending between opposing first and second lateral edges and first and second arms extending upward respectively from the first and second lateral edges of the base so as to form a cavity configured to receive a structural cross member of the panel. Engagement lips extend laterally inward from an upper end of each arm and are configured to grip respective first and second flanges of a grid member of the support grid so as to secure the panel to the grid member. Each of the first and second engagement lips span a substantial majority of the depth of the connection clip.