Ladders, ladder components and related methods are provided including embodiments of a hinge that may be used in a combination ladder. In one embodiment, a hinge mechanism includes a first hinge assembly and a second hinge assembly. The first and second hinge assemblies are coupled together for relative rotation about a defined axis. An adjustment mechanism enables the two hinge assemblies to be selectively locked or unlocked to prohibit or permit relative rotation, respectively. In one embodiment, the adjustment mechanism includes a lock plate displaceable along a first axis and a retainer displaceable along a second axis. The retainer is configured to hold the lock plate in a disengaged state until a release structure displaces the retainer away from the lock plate. The release structure may be configured to be actuated and displace the retainer upon relative rotation of the hinge assemblies to (or through) a predetermined angular configuration.