Various techniques are disclosed for systems and methods to provide image resolution enhancement. For example, a method includes: receiving a reference image (e.g., a visible light image) of a scene comprising image pixels identified by pixel coordinates; receiving a lower-resolution target image (e.g., an infrared image) of the scene; resizing the target image to a larger size; determining an adaptive-shape neighborhood for each pixel coordinate, wherein the adaptive-shape neighborhood extends from the each pixel coordinate such that those reference image pixels that are within the shape-adaptive neighborhood meet a regularity condition; determining, for each adaptive-shape neighborhood, a local estimate based on those target image pixels that are within the adaptive-shape neighborhood; and aggregating the local estimates associated with the adaptive-shape neighborhoods to provide a global estimate that corresponds to the target image with an improved resolution. A system configured to perform such a method is also disclosed.