The present disclosure relates to an information processing device, an information processing method, and a program capable of performing continuous estimation of a self-position.An information processing device according to an aspect of the present disclosure includes: a main imaging unit that includes a stereo camera mounted on a moving body, and captures moving images at a predetermined frame rate to output a pair of stereo main images as time-series images; a plurality of sub imaging units each of which is so mounted on the moving body as to have an imaging direction different from an imaging direction of the main imaging unit, and captures moving images at a predetermined frame rate; and a final pose determination unit that estimates a pose of the moving body on the basis of the pair of stereo main images captured by the main imaging unit, and sub images captured by the sub imaging units. For example, the present disclosure is applicable to a self-position sensor for in-vehicle use.