Ultrasonic locationing interleaved with alternate audio functions includes a plurality of transmitters for emitting ultrasonic bursts and alternate audio signals. A backend controller schedules the ultrasonic bursts and alternate audio signals from each transmitter. The backend controller can characterize an interference effect of defined interference parameters for each alternate audio signal, with respect to the ultrasonic bursts, and modify interleave scheduling of the ultrasonic bursts and alternate audio signals in accordance with the respective interference effect. A mobile device can receive the ultrasonic bursts for locationing of the mobile device, while a user or other device that can act on information in the alternate audio signals. Input from a user to an interface device can trigger the backend controller to schedule an alternate audio signal containing information related to the input.