Systems and methods for managing one or more inventories of RFID tagged articles for one or more compounds in which the tagged articles are stored in storage units therein. The system in each compound comprises a plurality of reader units each configured to be located inside or in proximity to a storage unit of the compound, wherein each reader unit comprises: at least one RF antenna for receiving signals data from the RFID tags of articles in the storage unit thereof; and a communication unit configured at least for transmitting the received data through at least one communication link; and a local management module adapted to receive data from the reader units. In certain embodiments, each local management module is configured for communicating with a central remote managing unit configured for managing inventories of a plurality of compounds.