Systems and methods are disclosed for routing of streaming data as between multiple compute resources. For example, the system may comprise a processor, a field programmable gate array (FPGA), a shared memory that is shared by a user space of an operating system for the processor and the FPGA, a network protocol stack, and driver code for execution by the processor. The driver code can be configured to (1) copy the streaming data received by the network protocol stack into the shared memory, (2) facilitate DMA transfers of the streaming data from the shared memory into the FPGA for processing thereby, (3) receive a stream of processed data from the FPGA, and (4) deliver the received processed data to the network protocol stack for delivery to one or more data consumers.