A method and system for determining a radiopharmaceutical compound in a medical image is disclosed. In one embodiment, the method includes obtaining the medical image from a medical imaging device through an interface. The method also includes identifying a region of interest in the medical image. The method further includes generating a feature vector associable with the region of interest. Additionally, the method includes detecting an uptake of the radiopharmaceutical compound in the region of interest. Furthermore, the method includes identifying a type of the radiopharmaceutical compound in the region of interest based on the feature vector and a biological information associated with the region of interest.