Embodiments of the present invention disclose an interference measurement indication method, an interference measurement method, a related device, and a communication system. The interference measurement indication method includes: transmitting, by a base station, at least one piece of first-type channel state information reference signal CSI-RS configuration signaling to a user equipment UE, where the at least one piece of first-type CSI-RS configuration signaling indicates a first resource set used for CSI-RS transmission; and transmitting, by the base station, at least one piece of second-type CSI-RS configuration signaling to the UE, where a second resource set used for CSI-RS transmission, which is indicated by the at least one piece of second-type CSI-RS configuration signaling, is a subset of the first resource set. Technical solutions provided by the embodiments of the present invention help improve the flexibility of interference measurement of the UE.