Invention Grant
- Patent Title: Target for diabetes treatment and prevention
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Application No.: US15114080Application Date: 2015-01-29
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Publication No.: US10821159B2Publication Date: 2020-11-03
- Inventor: Vincent Marion , Nikolai Petrovsky
- Applicant: UNIVERSITE DE STRASBOURG , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , VAXINE PTY LTD
- Applicant Address: FR Strasbourg FR Paris AU Bedford Park
- Assignee: UNIVERSITE DE STRASBOURG,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,VAXINE PTY LTD
- Current Assignee: UNIVERSITE DE STRASBOURG,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,VAXINE PTY LTD
- Current Assignee Address: FR Strasbourg FR Paris AU Bedford Park
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@316e2c9f
- International Application: PCT/EP2015/051856 WO 20150129
- International Announcement: WO2015/114062 WO 20150806
- Main IPC: A61K38/45
- IPC: A61K38/45 ; A61K38/03 ; A61K38/17 ; G01N33/50
Abstract:
The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by αPKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of αPKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of αPKC on ALMS1.
Public/Granted literature
- US20170000857A1 NEW TARGET FOR DIABETES TREATMENT AND PREVENTION Public/Granted day:2017-01-05
Information query
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