Invention Grant
- Patent Title: L-asparaginase variants and fusion proteins with reduced L-glutaminase activity and enhanced stability
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Application No.: US16080435Application Date: 2017-03-01
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Publication No.: US10821160B2Publication Date: 2020-11-03
- Inventor: Arnon Lavie , Hien-Anh Nguyen
- Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Applicant Address: US IL Urbana
- Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee Address: US IL Urbana
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2017/020090 WO 20170301
- International Announcement: WO2017/151707 WO 20170908
- Main IPC: C12N9/82
- IPC: C12N9/82 ; C12N15/00 ; A61K38/50 ; C07K14/52 ; A61K47/66 ; A61K47/68 ; A61K47/65 ; A61P35/00 ; C12N15/52 ; C12R1/18 ; A61K38/00
Abstract:
Variant Erwinia chrysanthemi L-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins containing an L-asparaginase and three tandem soluble domains of TRAIL for use in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.
Public/Granted literature
- US20190070274A1 L-ASPARAGINASE VARIANTS AND FUSION PROTEINS WITH REDUCED L-GLUTAMINASE ACTIVITY AND ENHANCED STABILITY Public/Granted day:2019-03-07
Information query
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