A dust collector includes an enclosure and a tube sheet separating filter and clean air compartments. The tube sheet forms a filter opening and a filter is located within the filter compartment and includes a filter flange having an air outlet aligned with said filter opening. The flange includes first and second alignment structures located on a first lateral side of the flange. A clamping assembly includes first and second filter clamps that are movable between a sealing position for sealing the filter flange against the tube sheet, and a release position. The first filter clamp engages the first alignment structure when in the sealing position. The second filter clamp engages the second alignment structure when in the sealing position. The dust collector includes means for moving the filter clamps between the sealing position and the release position.