A pressure bulkhead system comprises a pressure bulkhead adapted to be connected to a fuselage of a vehicle to separate a pressurized cabin space of the vehicle from an unpressurized cabin space of the vehicle, and a peripheral pressure frame to sealingly connect the pressure bulkhead to the vehicle fuselage. The peripheral pressure frame comprises an attachment section sealingly attached to an outer rim portion of a first surface of the pressure bulkhead. The first surface, when the pressure bulkhead system is installed in the vehicle, faces the unpressurized cabin space of the vehicle. A flange section is adapted to be sealingly attached to an inner surface of the vehicle fuselage and extends in a direction facing away from the first surface of the pressure bulkhead. A flexible section interconnects the attachment section and the flange section and is flexible to accommodate cabin pressure acting on the pressure bulkhead.