Invention Grant
- Patent Title: Aldosterone synthase inhibitor
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Application No.: US16345209Application Date: 2017-10-26
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Publication No.: US10822332B2Publication Date: 2020-11-03
- Inventor: Christoph Schumacher , Walter Fuhrer , Ronald Edward Steele
- Applicant: DAMIAN PHARMA AG
- Applicant Address: CH Walchwil
- Assignee: DAMIAN PHARMA AG
- Current Assignee: DAMIAN PHARMA AG
- Current Assignee Address: CH Walchwil
- Agency: Medler Ferro Woodhouse & Mills PLLC
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@34beb6b2
- International Application: PCT/EP2017/077511 WO 20171026
- International Announcement: WO2018/078049 WO 20180503
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61P9/00 ; A61P9/12 ; A61P13/12 ; A61K31/437

Abstract:
The present invention relates to a compound selected from (R)-(+)-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and a pharmaceutically acceptable salt thereof, and in particular to the phosphate salt of (R)-(+)-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine, both having preferably an enantiomeric excess of the (R) form higher than or equal to 97%. Furthermore, the present invention relates to pharmaceutical compositions comprising the same, their use as a medicament and in methods of treatment of diseases and disorders in humans including women of child bearing potential and pediatric patients in which aldosterone over-exposure contributes to the deleterious effects of said diseases or disorders, as well as processes for preparing said inventive compounds.
Public/Granted literature
- US20190292180A1 ALDOSTERONE SYNTHASE INHIBITOR Public/Granted day:2019-09-26
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