Invention Grant
- Patent Title: Substituted aminoquinazoline compounds as A2A antagonist
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Application No.: US15738178Application Date: 2016-07-05
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Publication No.: US10822338B2Publication Date: 2020-11-03
- Inventor: Amjad Ali , Xianhai Huang , Yeon-Hee Lim , Rongze Kuang , Heping Wu , Rajan Anand , Younong Yu , Edward Metzger , Michael Man-Chu Lo , Pauline C. Ting , Andrew W. Stamford , Paul Tempest
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; Catherine D. Fitch
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4acbc1d4
- International Application: PCT/US2016/040926 WO 20160705
- International Announcement: WO2017/011214 WO 20170119
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D491/153

Abstract:
The present invention is directed to compounds of generic formula (I): or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist. The invention is further directed to methods of treating a patient (preferably a human) for diseases or disorders in which the A2A-receptor is involved. The invention further involves use of the compounds as an A2A-receptor antagonist and/or inhibitor for the preparation of a medicament for the treatment and/or prevention of diseases associated with inhibiting the receptor, which includes central nervous system disorders such as Parkinson's disease. The invention is also directed to pharmaceutical compositions which include an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.
Public/Granted literature
- US20180362530A1 SUBSTITUTED AMINOQUINAZOLINE COMPOUNDS AS A2A ANTAGONIST Public/Granted day:2018-12-20
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