- Patent Title: Method for treating chronic intestinal inflammation and inflammatory bowel disease by administering antagonists of Oncostatin-M (OSM) and/or antagonists of OSM receptor-beta (OSMR)
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Application No.: US15547154Application Date: 2016-01-28
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Publication No.: US10822406B2Publication Date: 2020-11-03
- Inventor: Nathaniel Richard West , Benjamin Michael Joseph Owens , Ahmed Nabil Hegazy , Fiona Margaret Powrie
- Applicant: Oxford University Innovation Limited
- Applicant Address: GB Oxford
- Assignee: Oxford University Innovation Limited
- Current Assignee: Oxford University Innovation Limited
- Current Assignee Address: GB Oxford
- Agency: Thomas|Horstemeyer, LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@2ab1ff7d com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@6af8b9c9 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@419ba68d
- International Application: PCT/GB2016/050185 WO 20160128
- International Announcement: WO2016/120625 WO 20160804
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61K39/00 ; C07K16/24 ; G01N33/68 ; A61K31/56 ; A61K38/20
Abstract:
The invention relates to methods of treating chronic intestinal inflammation and/or inflammatory bowel disease by administering an antagonist of oncostatin-M (OSM) and/or OSM receptor-β (OSMR). The invention also relates to methods for diagnosing or prognosing chronic intestinal inflammation and/or inflammatory bowel disease in an individual and for predicting whether or not an individual will respond to an anti-TNFα therapy. The methods comprise measuring OSM and/or OSMR in the individual.
Public/Granted literature
- US20180022800A1 BIOMARKER Public/Granted day:2018-01-25
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