Invention Grant
- Patent Title: Dynamic urea bonds with fast hydrolytic kinetics for polymers
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Application No.: US16082969Application Date: 2017-03-07
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Publication No.: US10822448B2Publication Date: 2020-11-03
- Inventor: Jianjun Cheng , Kaimin Cai , Hanze Ying
- Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Applicant Address: US IL Urbana
- Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee Address: US IL Urbana
- Agency: Dilworth IP, LLC
- International Application: PCT/US2017/021105 WO 20170307
- International Announcement: WO2017/155958 WO 20170914
- Main IPC: C08F290/06
- IPC: C08F290/06 ; A61K47/34 ; A61L17/10 ; A61L27/18 ; C08J5/18 ; C08G18/76 ; C08G18/32 ; C08G18/66 ; C08G18/48 ; B65D65/46

Abstract:
The present invention relates to polymers having dynamic urea bonds and more specifically to polymers having hindered urea bonds (HUBs) with fast hydrolytic kinetics. These urea bonds are aryl-substituted, i.e. aromatic-substituted hindered urea bonds, that demonstrate pH independent hydrolytic kinetics, such that they consistently and rapidly hydrolyze in water from pH 2 to 11. The urea bond dissociation for these materials is generally such that k−1>h−1, which is two orders of magnitudes faster than for aliphatic hindered ureas. The present invention also relates to hydrolytically reversible or degradable linear, branched or network polymers incorporating these HUBs and to precursors for incorporation of these HUBs into these polymers. The technology can be applied to and integrated into a variety of polymers, such as polyureas, polyurethanes, polyesters, polyamides, polycarbonates, polyamines, and polysaccharides to make linear, branched, and cross-linked polymers. Polymers incorporating these HUBs can be used in a wide variety of applications including for example, environmentally compatible packaging materials and biomedical applications, such as drug delivery systems and tissue engineering. In other embodiments, the HUBs can be used in self-healing polymers.
Public/Granted literature
- US20190092898A1 DYNAMIC UREA BONDS WITH FAST HYDROLYTIC KINETICS FOR POLYMERS Public/Granted day:2019-03-28
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