A method of preventing surge for a vehicle may include detecting, by a controller, whether tip-out of an accelerator pedal is detected, comparing, by the controller, a difference value, obtained by subtracting an exhaust pressure from an intake pressure in a combustion chamber of an engine, with a predetermined reference value when the tip-out of the accelerator pedal is detected, driving, by the controller, a supercharger disposed at the rear end portion of a turbocharger at a predetermined number of revolutions per minute, which is lower than a normal number of revolutions per minute, when the difference value is greater than the reference value, and opening a bypass valve, which performs opening or closing operation and is disposed in a bypass line that diverges from an upstream point of the supercharger and is connected to a downstream point of the supercharger.