Disclosed are a thermal crosslink material, a manufacture method of a liquid crystal display panel, and a liquid crystal display panel. A structural formula of the thermal crosslink material is wherein A is B is and R is a linear or chain branched alkyl having 5-20 C atoms, wherein one or more CH2 in the alkyl is substituted with phenyl, cycloalkyl, —O—, —CONH—, —COO—, —O—CO—, —CO—, or —CH═CH— group, or one or more H atoms in the first group are substituted with F atom or Cl atom; a specific crosslink material may be one of Molecules of the thermal crosslink material crosslink together to form a polymer having a crosslinked network, and groups A and B can be anchored on a substrate surface. The branch R provides an effect of vertical alignment and can form alignment films.