Embodiments provide a method and machine for application migration. In an embodiment, a first descriptor associated with a first runtime environment of an application executed on a first dedicated processing unit is obtained from the first dedicated processing unit. In response to determining that the application is to be migrated from the first dedicated processing unit to the second dedicated processing unit during the execution, the second dedicated processing unit is caused to create a second descriptor associated with a second runtime environment for the application, executed on the second dedicated processing unit. Subsequently, the second descriptor is obtained from the second dedicated processing unit and a first mapping from the first descriptor to the second descriptor is established for re-directing, to the second dedicated processing unit, the request from the application to the first dedicated processing unit. A corresponding machine for implementing the method is further disclosed.