Systems, methods, computer readable media and articles of manufacture consistent with innovations herein are directed to computer virtualization, computer security and/or hypervisor fingerprinting. According to some illustrative implementations, innovations herein may utilize and/or involve a separation kernel hypervisor which may include the use of a guest operating system virtual machine protection domain, a virtualization assistance layer, and/or a CPU ID instruction handler (which may be proximate in temporal and/or spatial locality to malicious code, but isolated from it). The CPU ID instruction handler may perform processing, inter alia, to return configurable values different from the actual values for the physical hardware. The virtualization assistance layer may further contain virtual devices, which when probed by guest operating system code, return the same values as their physical counterparts. In addition, the virtualization assistance layer may vary its internal I/O and memory addresses in a configurable manner.