An OLED driving compensation circuit is provided. The OLED driving compensation circuit includes an OLED, a capacitor, a driving TFT (thin film transistor), a switch TFT, a lighting TFT, and an initial TFT. The OLED driving compensation circuit further includes a compensation circuit. The compensation circuit receives a feedback current passed through the second end of the driving TFT and generates a compensation voltage according to the feedback current, and the compensation circuit is compensated by the switch TFT outputs the compensation voltage to the capacitor. An AMOLED display panel is further disclosed. However, this disclosure has advantage of improving display stability for the AMOLED display panel.