A method, device of compensating viewing angle chromatic aberration of a display device, and a display device are provided, wherein the method includes the steps as follows: receiving an inputted image, looking-up each of pixel driving signals of the inputted image and obtaining a first driving signal and a second driving signal corresponded to each of pixels within two adjacent frames of the image individually, computing a mean value of the first driving signals and a mean value of the second driving signals individually, computing a mean value of the first the second driving signals in the same frame of the image individually, computing a brightness compensation signal required in a backlight module of a backlight region based on the computed mean values and a predetermined standard brightness signal; and compensating viewing angle chromatic aberration of post frames of the image based on the brightness compensation signal.