The present invention provides a manufacture method of a flexible display panel, and after forming grooves on the rigid substrate, and forming the flexible supporting bases in the grooves, and manufacturing the display element layer on the flexible supporting bases and the rigid substrate, the flexible display mother board is obtained. Then, the normal knife flywheel is used to cut the flexible display mother board along the edges of the grooves to obtain the flexible substrate units. After stripping the rigid substrates in the flexible substrate units with laser, the flexible display substrates are obtained. The method saves the purchase cost of the laser cutting apparatus, and thus to reduce the manufacture cost of the flexible display substrate, and meanwhile, to raise the cutting yield of cutting the flexible display mother board with the normal knife flywheel for promoting the usage lifetime of the knife flywheel.