A method for operating a system level interconnect in an integrated circuit (IC) is provided in an example embodiment. The method comprises: writing, by a microcontroller in the IC, a first configuration value into a configuration register, where the first configuration value programs the system level interconnect to couple a first peripheral to a second peripheral; monitoring the IC to determine an operational state of the IC; and in response to determining a change in the operational state of the IC, writing by the microcontroller a second configuration value into the configuration register to dynamically change interconnections in the system level interconnect between the first peripheral and the second peripheral.