Embodiments of network processing resource management in computing devices are disclosed therein. An example method includes receiving a request from a network interface controller to perform network processing operations at a first core of a main processor for packets assigned by the network interface controller to a queue of a virtual port of the network interface controller. The method also includes determining whether the first core has a utilization level higher than a threshold when performing the network processing operations to effect processing and transmission of the packets. If the first core has a utilization level higher than the threshold, the method includes issuing a command to the network interface to modify affinitization of the queue from the first core to a second core having a utilization level lower than the threshold.