A system and method can support asynchronous request/response in a network environment. A network protocol can utilize a load balancer to balance requests, such as HTTP requests, over a fast network interface, such as InfiniBand, to one or more nodes of an application server cluster. The system and method can attach headers to the requests such that the requests can be sent in an interleaved manner. The system and method can further allow for sending of large requests by breaking up the large requests into smaller portions, and sending each portion, interleaved, with other requests.