A media presentation and distribution system (MPDS) communicatively coupled to a client device, which handles media content distribution via a content delivery network, to a client device associated with a user: identifies candidate time intervals in programming media content played at the client device based on at least a request received from the client device. The MPDS retrieves media content from a media store in the MPDS. The media content is retrieved based on at least one of the user intent information and a plurality of targeting parameters associated with the user. The MPDS dynamically generates personalized media content that corresponds to the candidate time intervals in the programming media content and further instructs playback of the dynamically generated personalized media content at the identified candidate time intervals based on the specified version of the programming media content played at the client device.