A pressure detection device includes a pressure sensitive sensor and a pressure calculating unit. The pressure sensitive sensor includes an upper base substrate, a lower base substrate, and a pressure sensitive layer formed on a surface of one of the base substrates. The pressure sensitive layer includes a pair of pressure sensitive portions located symmetrically with respect to a plane center. A first elastic body and a second elastic body are disposed at a position to which a pressing force is applied. A first electrode and a second electrode are disposed with the pressure sensitive layer. The pressure calculating unit is configured to cause the pressure sensitive sensor to detect a pressure change for each of the pair of pressure sensitive portions and to add a sign-reversed pressure change in a pressure sensitive portion to a pressure change in the other pressure sensitive portion to amplify an output.