A computer system identifies the permutation of supplemental materials most effective at increasing adherence for each of a plurality of different medication diagnostic codes and provides the materials at an optimal point in time. An example system includes a supplemental program (SP) module implemented on a computing device that receives a plurality of supplemental programs associated with the one or more prescribed substances, identifies a plurality of permutations of the plurality of supplemental programs, constructs a plurality of cohorts, each of the cohorts corresponding to a prescribed substance and associated with a permutation, receives adherence data collected with respect to the plurality of permutations associated with the plurality of cohorts; and determines effectiveness of each of the plurality of permutations based on the adherence data.