Invention Grant
- Patent Title: Recombinant attenuated Mopeia virus comprising a modified nucleoprotein with reduced exonuclease activity
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Application No.: US15770210Application Date: 2016-10-24
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Publication No.: US10849969B2Publication Date: 2020-12-01
- Inventor: Sylvain Baize , Audrey Page , Xavier Carnec , Mathieu Jean Simon Mateo , Stephanie Reynard , Alexandra Fizet
- Applicant: INSTITUT PASTEUR
- Applicant Address: FR Paris
- Assignee: INSTITUT PASTEUR
- Current Assignee: INSTITUT PASTEUR
- Current Assignee Address: FR Paris
- Agency: Arrigo, Lee, Guttman & Mouta-Bellum LLP
- International Application: PCT/EP2016/075573 WO 20161024
- International Announcement: WO2017/068190 WO 20170427
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C12N7/00 ; C12N9/16 ; A61K39/00 ; C12N9/22
Abstract:
A recombinant attenuated Mopeia virus (MOPV) comprising a recombinant genomic S segment that encodes a nucleoprotein having attenuated exonuclease activity, and optionally further encodes a non-MOPV arenavirus glycoprotein. Use of the recombinant attenuated MOPV to induce an immune response in a subject.
Public/Granted literature
- US20180303927A1 RECOMBINANT MOPEIA VIRUS AND VACCINE PLATFORM Public/Granted day:2018-10-25
Information query
